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  • Title: Production of tumour necrosis factor and interleukin 1 by monocytes of patients with previous Yersinia arthritis.
    Author: Repo H, Jäättelä M, Leirisalo-Repo M, Hurme M.
    Journal: Clin Exp Immunol; 1988 Jun; 72(3):410-4. PubMed ID: 3262459.
    Abstract:
    We studied production of tumour necrosis factor (TNF) and interleukin 1 (IL-1) by using purified peripheral blood monocytes of patients with previous yersinia arthritis (YA) and of healthy HLA-B27 positive and negative controls. Lipopolysaccharide-exposed cells of HLA-B27 positive and negative patients, and those of HLA-B27 positive controls, generated significantly more TNF than did HLA-B27 negative control cells. There was a positive correlation between the levels of TNF and IL-1. Our results give credence to the view that augmented production of phlogistic mediators may contribute to inflammatory symptoms in patients with HLA-B27 associated disease.
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