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  • Title: Individual variation in the isotype profile of anti-histone autoantibodies in systemic lupus erythematosus.
    Author: Fellows G, Gittoes N, Scott DG, Coppock JS, Wainwright A, Goodall M, Turner BM.
    Journal: Clin Exp Immunol; 1988 Jun; 72(3):440-5. PubMed ID: 3262462.
    Abstract:
    Using a solid-phase radioimmunoassay we have measured levels of anti-histone autoantibodies of the IgG, IgA and IgM heavy chain classes in 40 patients with systemic lupus erythematosus. Twenty-two patients (55%) had significantly elevated levels of at least one anti-histone isotype. Our results reveal four characteristics of the anti-histone response. (1) There is wide variation between patients in the isotype profile of anti-histone antibodies and these isotype profiles are a consistent individual characteristic. (2) There is no significant correlation between the level of IgG, IgA and IgM anti-histone in individual patients and a marked tendency for a single isotype (either IgG, IgA or IgM) to predominate in any one patient. (3) IgG anti-histone antibodies are predominantly of the IgG1 subclass. (4) Among 12 patients tested, IgG and IgA antibodies showed a preference for histones 1 and 2B whereas IgM antibodies showed no consistent preference for individual histones.
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