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  • Title: Optic neuropathy as an initial manifestation of Sjögren's syndrome.
    Author: Wise CM, Agudelo CA.
    Journal: J Rheumatol; 1988; 15(5):799-802. PubMed ID: 3262752.
    Abstract:
    Although optic neuropathy is a known complication of systemic lupus erythematosus, its association with other connective tissue diseases is less well documented. We describe 3 previously asymptomatic women presenting with optic neuropathy in whom changes highly suggestive of primary Sjögren's syndrome (SS) were found by minor salivary gland biopsy 1-6 years after initial presentation. Typical symptoms of SS were absent initially and developed slowly, while serologic abnormalities were consistently present. Optic neuropathy may be a presenting neurologic feature of SS and may antedate typical signs and symptoms of SS. Primary SS should be considered in the differential diagnosis of optic neuropathy.
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