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  • Title: Lack of hybridization between Yersinia enterocolitica and HLA-B27 DNA.
    Author: Viitanen AM, Lahesmaa-Rantala R, Weiss E, Toivanen A.
    Journal: J Rheumatol; 1988 Jul; 15(7):1123-5. PubMed ID: 3262758.
    Abstract:
    No homology was observed between Yersinia enterocolitica O:3 and HLA-B27 at DNA level when Yersinia enterocolitica chromosomal probes were hybridized with human HLA-B27 positive leukocyte DNA or in the hybridization of Yersinia DNA with HLA-B27 specific probe. Our results do not exclude the existence of molecular mimicry between Yersinia proteins and HLA-B27 antigen, since the crossreactive epitope might be a conformational determinant not detected with hybridization.
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