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  • Title: Activation of peripheral blood lymphocytes in patients with primary Sjögren's syndrome.
    Author: Youinou P, Pennec YL, Blaschek MA, Gentric A, Jouquan J, Lamour A, Angelidis P.
    Journal: Rheumatol Int; 1988; 8(3):125-30. PubMed ID: 3262909.
    Abstract:
    The peripheral blood from 15 patients with primary Sjögren's syndrome and from 15 matched controls was examined for the presence of activated T and B lymphocytes, by using monoclonal antibodies directed to interleukin-2 (IL-2) and transferrin receptors, and to HLA-DR determinants. The number of circulating positive-T cells was significantly greater in the patients than in the controls, irrespective of disease activity. There were more of the CD8 cells than of the CD4 cells that expressed IL-2 receptors. There was a small but significant increase in activated B cells in the patients, since this population is virtually absent from the normal blood.
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