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  • Title: Sequence specificity of Z-DNA formation in oligonucleotides.
    Author: Kadalayil LP, Majumder K, Mishra RK, Brahmachari SK.
    Journal: Biochem Int; 1988 Jul; 17(1):121-31. PubMed ID: 3263858.
    Abstract:
    The sequence specific requirement for B----Z transition in solution was examined in d(CGTGCGCACG), d(CGTACGTACG), d(ACGTACGT) in presence of various Z-inducing factors. Conformational studies show that inspite of the alternating nature of purines and pyrimidines, the aforementioned sequences do not undergo B----Z transition under the influence of NaCl, hexamine cobalt chloride and ethanol. A comparison with the crystal structures of an assorted array of purine and pyrimidine sequences show that the sequence requirement for B----Z transition is much more stringent in solution as compared to the solid state. The disruptive influence of AT base pairs in B to Z transition is discussed.
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