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  • Title: Ultrasensitive analysis of microRNAs with gold nanoparticle-decorated molybdenum disulfide nanohybrid-based multilayer nanoprobes.
    Author: Su S, Sun Q, Ma J, Zhu D, Wang F, Chao J, Fan C, Li Q, Wang L.
    Journal: Chem Commun (Camb); 2020 Aug 14; 56(63):9012-9015. PubMed ID: 32638751.
    Abstract:
    The nanoprobe-based signal amplification strategy is a powerful way to ultrasensitively detect biomolecules. Herein, a gold nanoparticle-decorated molybdenum disulfide (MoS2-AuNP)-based multilayer nanoprobe (MLNP) was designed for ultrasensitive analysis of microRNA-21 (miRNA-21). The MLNP-amplified electrochemical biosensor exhibited an ultrawide dynamic range (10 aM-1 μM) and an ultralow detection limit (38 aM) for target miRNA-21 analysis. Furthermore, this biosensor can determine miRNA-21 expression in cell lysates of 100 human cervical cancer (HeLa) cells. Our results demonstrate that MoS2-AuNP nanocomposites have great potential in constructing biosensors for target molecule analysis.
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