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  • Title: Some immunological considerations relevant to the study of human bladder cancer.
    Author: Bean MA.
    Journal: Cancer Res; 1977 Aug; 37(8 Pt 2):2879-84. PubMed ID: 326394.
    Abstract:
    The likelihood that immunosurveillance, concomitant immunity, and immunodepression play a role in the development and spread of neoplasms of the urinary bladder is discussed. The circumstantial evidence for the existence of concomitant immunity to bladder cancer-associated antigens is briefly reviewed, and the implications of the hypothesis of Zinkernagel and Dougherty of a genetic restriction to the cytotoxicity of T-cells for virally determined target cell antigens and of the concept of immunoregulatory cells for our understanding of the immunology of bladder carcinoma are discussed.
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