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  • Title: [Modification of the regulatory effects of thymocytes on hematopoiesis in irradiated mice as affected by heterologous immunoglobulin G and low-dose ionizing radiation].
    Author: Lebedev VG, Moroz BB, Gutsenko KK, Ivanov AA.
    Journal: Radiobiologiia; 1988; 28(5):672-6. PubMed ID: 3264076.
    Abstract:
    The administration of heterologous immunoglobulin G (IgG) and/or exposure of mouse thymocyte donors to 1 and 2 Gy radiation were shown to change the regulatory effects of thymus lymphocytes on the recovery of haemopoiesis in syngeneic recipients irradiated with a median lethal dose of 6 Gy. Thymocytes of exposed (2 Gy) donors produced a stimulatory effect on the restoration of the myelokaryocytes number and increased the number of endogenous splenic colonies and bone marrow CFUs in animals exposed to a median lethal dose, whereas the administration of IgG to thymocyte donors given 2 Gy eliminated the stimulatory effect of thymocytes on the number of myelokaryocytes, and the amount of CFUs in irradiated recipients decreased.
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