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  • Title: High-concentration nonavian high-molecular weight hyaluronan injections and time-to-total knee replacement surgery.
    Author: Etter K, Chitnis AS, Holy CE, Gray FS, Manalac FJ, Bisson B, Bhattacharyya SK.
    Journal: J Comp Eff Res; 2020 Aug; 9(11):795-805. PubMed ID: 32643955.
    Abstract:
    Aim: To examine the time-to-total knee replacement (TKR) surgery among patients with high-concentration nonavian high-molecular-weight hyaluronan injection (HMW-HA) compared with those without HA injections. Materials & methods: Using MarketScan® Commercial claims all patients aged 18-64 who underwent TKR surgery between 2008 and 2017 were identified. Time-to-TKR surgery was compared between patients receiving Orthovisc® (Anika Therapeutics Inc. Bedford MA, USA, referred to as nonavian HMW-HA) injections and patients who did not receive an HA injection. Results: The median time-to-TKR surgery was 893 days in the nonavian HMW-HA cohort and 399 days in the non-HA cohort (p < 0.001), a difference of 494 days (16.2 months). Conclusion: This study demonstrates that the time-to-TKR surgery is 16.2 months longer in patients who received treatment with nonavian HMW-HA injections.
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