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  • Title: Ankylosing spondylitis without B27: no evidence for gene conversion.
    Author: Pease CT, Ellis SA, McMichael AJ, Brewerton DA.
    Journal: Ann Rheum Dis; 1988 Dec; 47(12):1001-3. PubMed ID: 3264696.
    Abstract:
    Isoelectric focusing gel electrophoresis was used to look for variant HLA molecules in five patients with HLA-B27 negative ankylosing spondylitis (AS). The isoelectric points of the HLA-A and B antigens from these patients and HLA paired controls were identical. This implies that the HLA-A and B antigens from the patients with AS and the controls are similar. Gene conversion of a nucleotide sequence from a B27 positive gene is thus unlikely to be the explanation for the existence of AS in patients who are HLA-B27 negative by alloantisera typing.
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