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  • Title: [Human epidermal growth factor (h-EGF) in gastric carcinomas].
    Author: Fushida S, Yonemura Y, Sugiyama K, Matsumoto H, Kamata T, Miwa K, Miyazaki I.
    Journal: Nihon Geka Gakkai Zasshi; 1988 Dec; 89(12):1965-8. PubMed ID: 3265984.
    Abstract:
    Two hundred and twenty one gastric carcinomas were immunohistochemically stained for h-EGF and we examined the correlation between h-EGF immunoreactivities and histologic findings. Regarding macroscopic and histologic types, incidence of h-EGF immunoreactivities in infiltrating type and in poorly differentiated type was significantly higher than those in localized type and in differentiated type, respectively. In addition, h-EGF producing carcinomas showed high positive rate in prognostic serosal involvement and scirrhous type in stroma. Prognosis in patients with h-EGF producing tumors was poorer than that in those with h-EGF non-producing tumors, especially in stages II and III. These results suggest that h-EGF immunoreactivities serves as a biological marker of high malignancy.
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