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  • Title: [Synthesis and pharmacologic activity of 9-R-octahydroindolo[2,3-a]quinolazine].
    Author: Boido-Canu C, Boido V, Sparatore F, Sparatore A, Susanna V, Russo S, Cenicola ML, Marmo E.
    Journal: Farmaco Sci; 1988 Oct; 43(10):819-37. PubMed ID: 3266484.
    Abstract:
    By acid induced cyclization of quinolizidin-1-one 4-R-phenylhydrazones several derivatives of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine (1), bearing a substituent on position 9, were prepared. When R = Cl this reaction gave rise also to a red-orange compound to which the structure (V) of 1-(p-chloro)phenylazo-3,4,6,7,8,9-hexahydroquinolizine was assigned. Substances (1 b)-(1-f) were tested for spontaneous locomotor, muscle relaxant, analgesic, antiinflammatory, diuretic and cardiovascular activities and for influence on pentylentetrazole and sodium pentobarbital actions. Interesting levels of activity were exhibited in several cases.
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