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  • Title: Increased fibroblast colony stimulating activity (F-CSA) in serum of myeloproliferative disorders.
    Author: Han ZC, Briere J, Parent D, Abgrall JF, Sensebe L.
    Journal: J Biol Regul Homeost Agents; 1988; 2(3):119-24. PubMed ID: 3267102.
    Abstract:
    Sera of patients with primary myelofibrosis (PMF), primary thrombocythemia (PT), polycythaemia vera (PV) and chronic myeloid leukemia (CML) contained a significantly increased F-CSA (or F-CSAs) compared to those of normal subjects and patients with secondary thrombocytosis (ST). This F-CSA was heat sensitive and had the capacity to promote both proliferation and maturation of normal marrow fibroblast colony-forming cells (CFU-F). This F-CSA seemed to be different from human platelet derived growth factor (PDGF), tumor necrosis factor (TNF) and fibroblast growth factor (FGF) from bovine brain. This F-CSA might be of importance in the pathogenesis of bone marrow fibrosis in myeloproliferative disorders.
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