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  • Title: Cytochemical differentiation of the axon membrane in A- and C-fibres.
    Author: Waxman SG, Quick DC.
    Journal: J Neurol Neurosurg Psychiatry; 1977 Apr; 40(4):379-85. PubMed ID: 327027.
    Abstract:
    Guinea pig and rat sciatic nerves were fixed with cacodylate-buffered aldehydes and OsO4, and were stained with ferric ion and ferrocyanide. Cytoplasmic surfaces of the non-myelinated nodal axon membrane of A-fibres display distinct electron-dense aggregates of stain. These aggregates were not observed in association with the paranodal or internodal axolemma. The membranes of C-fibres exhibit no staining under these conditions. Thus, the nodal axolemma of normal myelinated fibres is structurally distinct from both the myelinated internodal membrane, and from the axolemma of C-fibres. The ferric ion-ferrocyanide technique may provide a method for marking axonal membrane with normal nodal properties.
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