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  • Title: Phosphonium-ammonium-based di-cationic ionic liquids as antibacterial over the ESKAPE group.
    Author: Brunel F, Lautard C, Garzino F, Raimundo JM, Bolla JM, Camplo M.
    Journal: Bioorg Med Chem Lett; 2020 Sep 15; 30(18):127389. PubMed ID: 32717610.
    Abstract:
    Emergence of antibioresistance is currently a major threat of public health worldwide. Hence there is an urge need of finding new antibacterial material. Herein, we report a simple and eco-friendly method to synthesize homo and heterodicationic ionic liquids based on quaternary phosphonium and ammonium salt. In order to investigate the structure activity relationship (SAR) we measured the MICs of a series of 16 derivatives with structural variations (nature of cations and counter-ions, size of linker and alkyl side chains as well as structural symmetry) over a range of Gram-positive and Gram-negative bacterial strains from the ESKAPE group. Some of the tested structures exhibit high antimicrobial activities (MIC = 0.5 mg/L) and are active over a wide range of bacteria from Gram-positive to Gram-negative. Overall, these results reveal the strong potential of di-cationic derivatives as antibacterial agents and the determination of activities from structural features gives decisive information for future synthesis of such di-cationic structures for biocidal purpose.
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