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  • Title: Comparison of ischemic preconditioning and BotulinumA Toxin injection for the prevention of ischemia-reperfusion injury in musculocutaneous flaps.
    Author: Derebaşınlıoğlu H, Demİröz A, Aydin Y, Ekmekçi H, Balci Ekmekçi Ö, Aydin Ö, Cankorkmaz L.
    Journal: Turk J Med Sci; 2020 Oct 22; 50(6):1523-1534. PubMed ID: 32718122.
    Abstract:
    BACKGROUND/AIM: The aim of the study was to evaluate the protective effect of Botulinum A toxin injection against ischemia-reperfusion injury. MATERIALS AND METHODS: Thirty-two Sprague-Dawley rats were divided into: control, ischemia-reperfusion, ischemic preconditioning, and botulinum groups. In all groups the musculocutaneous pedicle flap was occluded for 4 h, and then reperfused to induce ischemia-reperfusion injury. Serum and tissue myeloperoxidase (MPO) and nitric oxide (NO) levels were measured at 24 h and at 10 days. RESULTS: Tissue MPO levels did not differ significantly between the ischemic preconditioning and botulinum groups at 24 h but was significantly lower in the botulinum group at 10 days. Tissue NO levels were significantly higher in the ischemic preconditioning group compared to the botulinum group at 24 h and at 10 days. Serum MPO showed no significant difference between these two groups at 24 h but was significantly lower in the ischemic preconditioning group compared to the botulinum group at 10 days. Serum NO levels were not significantly different at 24 h but significantly higher in the botulinum group at 10 days. CONCLUSION: Findings show that botulinum has a protective effect against the ischemia-reperfusion injury via increased NO and decreased MPO levels in tissue. Based on tissue NO levels, ischemic preconditioning was significantly higher than botulinum.
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