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  • Title: Phenoxazine-based Near-infrared Fluorescent Probes for the Specific Detection of Copper (II) Ions in Living Cells.
    Author: Shen Y, Zheng W, Yao Y, Wang D, Lv G, Li C.
    Journal: Chem Asian J; 2020 Sep 15; 15(18):2864-2867. PubMed ID: 32720435.
    Abstract:
    It is well known that copper ions play a critical role in various physiological processes. However, a variety of human diseases are tightly correlated with copper overload. Although there are numerous fluorescent probes capable of detecting copper ions, most of them are "turn-off" probes owing to copper (II) ions fluorescence quenching effect, resulting in poor sensitivity. Herein, a novel "turn-on" near-infrared (NIR) fluorescent probe PZ-N based on phenoxazine was designed and synthesized for the selective detection of copper (II) ions (Cu2+ ). Upon the addition of Cu2+ , the probe could quickly react with Cu2+ and emit strong fluorescence, along with colour change from colourless to obvious blue. Moreover, the probe PZ-N showed good water solubility, high selectivity, and excellent sensitivity with low limit of detection (1.93 nM) towards copper (II) ions. More importantly, PZ-N was capable of effectively detecting Cu2+ in living cells.
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