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  • Title: Juvenile Xanthogranuloma: An Entity With a Wide Clinical Spectrum.
    Author: Hernández-San Martín MJ, Vargas-Mora P, Aranibar L.
    Journal: Actas Dermosifiliogr (Engl Ed); 2020 Nov; 111(9):725-733. PubMed ID: 32721389.
    Abstract:
    Juvenile xanthogranulomas (JXGs) are rare, benign lesions that belong to the large group of non-Langerhans cell histiocytoses. JXG presents with 1 or more erythematous or yellowish nodules that are usually located on the head or neck. Most JXG lesions are congenital or appear during the first year of life. Extracutaneous involvement is rare, but the literature traditionally suggests investigating the possibility of ocular compromise. JXG is mainly a clinical diagnosis, but a skin biopsy may sometimes be needed for confirmation. JXGs on the skin are self-limiting and usually do not require treatment. This review describes the clinical and therapeutic aspects of JXG, emphasizing available evidence and the diagnosis of extracutaneous involvement.
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