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  • Title: Compressed Paper as an Alternative to Corn Cob Bedding in Mouse (Mus musculus) Cages.
    Author: Pallas BD, Keys DM, Bradley MP, Vernasco-Price EJ, Sanders JD, Allen PS, Freeman ZT.
    Journal: J Am Assoc Lab Anim Sci; 2020 Sep 01; 59(5):496-502. PubMed ID: 32723424.
    Abstract:
    Bedding material is a critical component of the mouse environment and affects animal wellbeing and research integrity. Corn cob (CC) bedding has been a common bedding choice in research despite several potential negative aspects of its use. We investigated the use of compressed paper (CP) bedding as a refinement to CC bedding. CP bedding demonstrated greater total and immediate absorption, compared with CC bedding. CP-bedded cages had a reduced frequency of early cage changing prior to the Guide-recommended 2-wk interval for IVC; this reduction was proportional to room census. Intracage ammonia levels were lower in CP-bedded IVC compared with CC-bedded IVC, independent of the age, sex, and number of mice per cage. By contrast, ammonia levels were similar between CP-bedded and CC-bedded static cages. Collectively, these data support the use of CP bedding as a refinement for CC in ventilated mouse cages, in light of increased husbandry efficiency and its positive effect on the welfare of mice.
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