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  • Title: Rat corticotropin-releasing hormone gene: sequence and tissue-specific expression.
    Author: Thompson RC, Seasholtz AF, Herbert E.
    Journal: Mol Endocrinol; 1987 May; 1(5):363-70. PubMed ID: 3274895.
    Abstract:
    The rat corticotropin releasing hormone (CRH) gene has been isolated and characterized by DNA sequence analysis. The gene exhibits a structural organization similar to that of the human CRH gene. The nucleotide sequence encoding the entire rat CRH precursor is located on the second exon, while exon I encodes the 5'-untranslated region of the mRNA. Analysis of the nucleotide sequence homology between the human and rat CRH genes reveals several highly conserved regions including the CRH peptide-encoding sequence and the 5'-flanking sequence. RNA blot analysis demonstrates that CRH mRNA can be observed in numerous regions of the rat brain as well as the spinal cord, adrenal gland, pituitary, and testis.
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