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  • Title: Clinical experience with amikacin, a new aminoglycoside antibiotic.
    Author: Theron FP, De Kock MA.
    Journal: S Afr Med J; 1977 May 21; 51(21):746-8. PubMed ID: 327583.
    Abstract:
    Amikacin, a new semisynthetic aminoglycoside antibiotic, was administered parenterally to 20 patients suffering from severe Gram-negative bacterial infections. The antibiotic was found to be highly effective in controlling infection. It was well tolerated and no signs of nephro- or otoxicity were observed. The few side-effects which were seen appeared to be dose-related. The recommended 12-hourly dosage regimen has also proved useful in medium- to long-term management of refractory pulmonary infections.
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