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  • Title: Proton NMR studies of the GDP.Mg2+ complex of the Ha-ras oncogene product p21.
    Author: Schlichting I, Wittinghofer A, Rösch P.
    Journal: Biochem Biophys Res Commun; 1988 Jan 15; 150(1):444-8. PubMed ID: 3276311.
    Abstract:
    Two-dimensional proton NMR studies were performed on the c-Ha-ras encoded proto-oncogene product p21C. COSY and NOESY spectra of the p21C.GDP.Mg2+ complex show that the ribose H1 proton of the bound GDP is in close proximity to the aromatic side chain of a phenylalanyl residue. From sequence homology with the bacterial elongation factor Tu (EF-Tu) and the known X-ray structure of the EF-Tu.GDP.Mg2+ complex it may be inferred that the Phe residue in question is either Phe78 or Phe82 in the p21 sequence.
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