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  • Title: [Monoclonal antibodies against the alpha-chain of human lymphocyte function-associated antigen-1].
    Author: Baryshnikov AIu, Dubinkin IV, Savel'eva EV, Veskova TK, Tupitsyn NN.
    Journal: Biull Eksp Biol Med; 1988 Jan; 105(1):55-8. PubMed ID: 3276359.
    Abstract:
    The goal of the investigation was to further characterize ICO-II monoclonal antibodies. ICO-II have been shown to block NK activity of mononuclear cells from the blood of healthy donors against K-562 and Molt-4 target cells, cytotoxic T lymphocytes induced in a 7-day mixed lymphocyte culture, the reaction of lymphocyte blast cell transformation to phytohemagglutinin and the formation of En-rosettes. The molecular weight of the antigen detected by ICO-II is 180 KD. ICO-II are shown to detect alpha-subunit of human lymphocyte function-associated antigen-I (LFA-I).
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