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  • Title: Effect of 5-hydroxytryptamine on the rate of cerebrospinal fluid production in rabbit.
    Author: Lindvall-Axelsson M, Mathew C, Nilsson C, Owman C.
    Journal: Exp Neurol; 1988 Feb; 99(2):362-8. PubMed ID: 3276547.
    Abstract:
    Infusion of 5-hydroxytryptamine in mock cerebrospinal fluid of rabbits lowered cerebrospinal fluid production dose-dependently by nearly 30%. The effect was amplified in the presence of the monoamine oxidase inhibitor, nialamide. The 5-hydroxytryptamine-induced inhibition was partly counteracted by ketanserin, and further addition of practolol completely blocked the reduction in cerebrospinal fluid formation, suggesting that both 5-hydroxytryptamine receptors and beta 1-adrenergic receptors were involved in the response mediated by both the secretory epithelium and the vascular bed of the plexus.
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