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  • Title: Epidermal necrolysis as the presenting manifestation of pediatric lupus.
    Author: Bhattarai D, Vignesh P, Chaudhary H, Bharadwaj N, Saini L, Gupta K, Rawat A.
    Journal: Pediatr Dermatol; 2020 Nov; 37(6):1119-1124. PubMed ID: 32770777.
    Abstract:
    Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) represents the spectrum of skin lesions characterized by rashes, exfoliation, and sloughing usually following drug intake. Occasionally, TEN-like cutaneous manifestations have also been described with systemic lupus erythematosus. Recognition of lupus in a child presenting with TEN-like skin changes is clinically challenging and requires a high degree of suspicion. We describe the case of a child who had epidermal necrolysis as the presenting feature of lupus and had severe neurological complications. TEN-like skin changes in association with severe neurological complications in pediatric lupus are uncommon. Lupus must be considered in the differential diagnosis of a child presenting with epidermal necrolysis with no provocative risk factors such as a history of exposure to medications.
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