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  • Title: Bancroftian filariasis in Haiti: preliminary characterization of the immunological responsiveness of microfilaremic individuals.
    Author: Lammie PJ, Leiva LE, Ruff AJ, Eberhard ML, Lowrie RC, Katz SP.
    Journal: Am J Trop Med Hyg; 1988 Jan; 38(1):125-9. PubMed ID: 3277457.
    Abstract:
    Patent infections with the lymphatic filariae, Wuchereria bancrofti and Brugia malayi, are associated with suppressed in vitro cellular responsiveness to filarial antigens. In studies of bancroftian filariasis in Haiti, a significant number of microfilaremic individuals can be characterized as "responders" to filarial antigens. Cells from 37/74 untreated microfilaremic subjects responded to B. pahangi antigen (stimulation ratio greater than 2) as detected by in vitro blastogenesis. A comparison of responders to nonresponders revealed a significant difference in mean B. pahangi reactivity (15,822 vs. 4,538 cpm, P less than 0.001), but no significant differences with respect to age, microfilaremia, PPD or PHA reactivity, or B. pahangi-specific antibody levels. Subtle differences may exist between these groups with respect to recognition of specific antigens on Western blots.
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