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  • Title: Ultrabright and Serum-Stable Squaraine Dyes.
    Author: Yadav Y, Owens E, Nomura S, Fukuda T, Baek Y, Kashiwagi S, Choi HS, Henary M.
    Journal: J Med Chem; 2020 Sep 10; 63(17):9436-9445. PubMed ID: 32787096.
    Abstract:
    Highly stable symmetric and asymmetric squaraine fluorophores have been synthesized featuring an internal salt bridge between a quaternary ammonium cation and the central oxycyclobutenolate ring of the chromophore. Some of our newly synthesized symmetric and asymmetric compounds display increased molar absorptivity, quantum yield in serum, and thermal/photochemical stability over previously reported squaraine-based dyes. Consequently, both classes show great promise in resurfacing the normal environment-labile squaraine dyes as novel imaging agents and scaffolds for fluorescence sensing. Furthermore, incorporating a covalent attachment point away from the conjugated system allows for biological tagging applications without disturbing the optimum optical characteristics of the newly designed fluorophore.
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