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  • Title: Monoamine oxidase inhibitors and anaesthesia. A review.
    Author: Stack CG, Rogers P, Linter SP.
    Journal: Br J Anaesth; 1988 Feb; 60(2):222-7. PubMed ID: 3278728.
    Abstract:
    There has been a recent renewal of interest in the use of monoamine oxidase inhibitors in psychiatry. The concurrent administration of anaesthetic agents, particularly narcotic analgesics, is often a cause for concern. Although many monoamine oxidase inhibitor-drug interactions have been reported, in practice it is only the interaction with pethidine which has led to fatalities. What is not appreciated is that the monoamine oxidase inhibitor-pethidine interaction has two distinct forms-"excitatory" and "depressive". It is this lack of appreciation that has led to much confusion when dealing with patients taking monoamine oxidase inhibitors.
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