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  • Title: Association between IL-33 Gene Polymorphism (Rs7044343) and Risk of Allergic Rhinitis.
    Author: Falahi S, Mortazavi SHR, Salari F, Koohyanizadeh F, Rezaeimanesh A, Gorgin Karaji A.
    Journal: Immunol Invest; 2022 Jan; 51(1):29-39. PubMed ID: 32787469.
    Abstract:
    BACKGROUND: Allergic rhinitis (AR) is a T helper type 2 (Th2)-mediated upper airways disease in which genetics factors including cytokine genes play a prominent role. Interleukin-33 (IL-33) is a major cytokine for naive T cells polarization into Th2 phenotype as well as enhances the secretion of Th2 cytokines. The aim of the present study was to investigate the relationship between IL-33 single nucleotide polymorphisms (SNPs) and IL-33 serum level with Allergic rhinitis. METHODS: Blood samples were collected from 130 AR patients and 130 healthy individuals. SNPs (rs7044343 C > T, rs1929992 A > G, rs12551256 A > G) of IL-33 gene were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum level of IL-33 was measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Statistical analysis showed that the TT genotype (OR = 1.996, CI: 1.168-3.412, P = .01), as well as the T allele (OR = 0.675, CI: 0.476-0.957, P = .02) of rs7044343 C > T were significantly associated with reduced risk of AR. In addition, individuals carrying the TT genotype were associated with lower levels of IL-33 compared to subjects with CC and CT genotypes; however, these differences were not statistically significant. No association was found between rs1929992 and rs12551256 variants and risk of AR, but the GG genotype from rs1929992 A > G was associated with increased serum levels of IL-33 in control group (p = .01). Furthermore, serum IL-33 levels were not significantly different between AR patients and healthy controls (p > .05). CONCLUSION: Our results suggest that the TT genotype of rs7044343 C > T may act as a protective agent against allergic rhinitis.
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