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  • Title: Baclofen, a new antispastic drug. A controlled, multicenter trial in patients with multiple sclerosis.
    Author: Sachais BA, Logue JN, Carey MS.
    Journal: Arch Neurol; 1977 Jul; 34(7):422-8. PubMed ID: 327987.
    Abstract:
    A double-blind, five-week, multicenter trial was conducted to compare the effect of baclofen, a unique amino acid derivative, with that of placebo in the treatment of 106 patients with spasticity secondary to multiple sclerosis. A spasticity assessment method that included a neurological examination, physicians' clinical impressions of changes during treatment, and a patient's self-evaluation was used to determine efficacy. This method showed baclofen (70 to 80 mg daily maximum, titrated) is effective relative to placebo in relieving symptoms of spasticity, such as flexor spasms, pain and stiffness, resistance to passive joint movements, and tendon stretch reflexes. Patient self-evaluation results also showed a significant reduction in clonus. Side effects were generally mild and transient.
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