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  • Title: Fluid reservoir thickness and corneal oedema during closed eye scleral lens wear.
    Author: Fisher D, Collins MJ, Vincent SJ.
    Journal: Cont Lens Anterior Eye; 2021 Feb; 44(1):102-107. PubMed ID: 32828691.
    Abstract:
    PURPOSE: To examine the relationship between central post-lens fluid reservoir thickness and central corneal oedema during short-term closed eye scleral lens wear, and to compare these empirical oedema measurements with open eye lens wear data and current theoretical modelling for overnight scleral lens wear. METHODS: Ten participants (mean ± standard error 30 ± 1 years) with normal corneas wore scleral lenses (Dk 141 × 10-11 cm3 O2(cm)/[(sec.)(cm2)(mmHg)) under closed eye conditions on separate days with an initial central post-lens fluid reservoir thickness considered to be low (160 ± 7 μm), medium (494 ± 17 μm), or high (716 ± 16 μm). Epithelial, stromal, and total corneal oedema were measured using high-resolution optical coherence tomography immediately after lens application and following 90 min of wear, prior to lens removal. Data were compared to open eye scleral lens induced corneal oedema and a theoretical model of overnight closed eye scleral lens wear (Kim et al., 2018). RESULTS: Central corneal oedema was primarily stromal in nature and increased with increasing fluid reservoir thickness; the mean total corneal oedema was 3.86 ± 0.50%, 4.71 ± 0.28% and 5.04 ± 0.42% for the low, medium, and high thickness conditions, respectively. A significant difference in stromal and total corneal oedema was observed between the low and high fluid reservoir thickness conditions only (both p ≤ 0.01). Theoretical modelling overestimated the magnitude of central corneal oedema and the influence of fluid reservoir thickness upon corneal oedema during closed eye conditions. CONCLUSION: Scleral lens induced central corneal oedema during closed eye lens wear increases with increasing fluid reservoir thickness, but at a decreased rate compared to theoretical modelling.
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