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  • Title: The chemical and enzymatic interaction of glutathione with the fungal metabolite, fusarin C.
    Author: Gelderblom WC, Thiel PG, van der Merwe KJ.
    Journal: Mutat Res; 1988 May; 199(1):207-14. PubMed ID: 3283546.
    Abstract:
    Glutathione (GSH) interacts both chemically and enzymatically with fusarin C, a mutagenic metabolite produced by Fusarium moniliforme. The chemical reaction, which is pH-dependent, results in the formation of both fusarin A and a compound that lacks the 2-pyrrolidone moiety thereby suggesting an interaction at the C-13-C-14 epoxide. Enzymatic interaction of fusarin C with GSH also appears to occur at this site as fusarins A and D, which lack the epoxide, do not serve as substrates for GSH-S-transferases. The interaction of GSH with fusarin C appears to be an important deactivation step which could explain the lack of carcinogenicity observed for fusarin C in rats.
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