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  • Title: Nickel Content in Human Internal Organs.
    Author: Dudek-Adamska D, Lech T, Konopka T, Kościelniak P.
    Journal: Biol Trace Elem Res; 2021 Jun; 199(6):2138-2144. PubMed ID: 32839915.
    Abstract:
    With the growing interest in new applications of metals in modern technologies, an increase in their concentration in the environment can be observed, which, in consequence, may constitute a hazard to human health. That is why it is of a great importance to establish "reference" levels of particular elements (essential or toxic) in human biological samples.The aim of this paper was to determine nickel in autopsy tissues of non-occupationally exposed subjects in Southern Poland (n = 60). Measurements were performed by means of electrothermal atomic absorption spectrometry after microwave-assisted acid digestion according to previously optimized and validated procedure. The results obtained indicate that data cover the wide range of concentrations and generally are consistent with other published findings. Nickel levels in the brain, stomach, liver, kidneys, lungs and heart (wet weight) were between 2.15-79.4 ng/g, 0.5-44.2 ng/g,7.85-519 ng/g, 12.8-725 ng/g, 8.47-333 ng/g and 2.3-97.7 ng/g, respectively. Females had generally lower levels of nickel in tissues than males (statistically significant relationships were found for the liver, kidneys and lungs), and median nickel concentrations in all studied material within all age groups had very similar values, with the exception of stomach.
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