These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Some mechanisms involved in the radiosensitization of E. coli B/r by paracetamol.
    Author: Shenoy MA, Gopalakrishna K.
    Journal: Int J Radiat Biol Relat Stud Phys Chem Med; 1977 Jun; 31(6):577-87. PubMed ID: 328417.
    Abstract:
    Paracetamol, a widely-used analgestic and antipyretic drug, sensitized E. coli B/r to 60Co gamma-rays under hypoxic conditions. Part of the sensitizing effect has been shown to be due to an electron adduct of the drug. Paracetamol inhibited both post-irradiation DNA and protein syntheses. The targets involved in the inhibition of post-irradiation DNA synthesis have been shown to be different in the presence of the sensitizer. Increased DNA degradation after irradiation was also observed when E. coli B/r were irradiated in the presence of the drug. The presence of paracetamol during hypoxic irradiation of E. coli B/r resulted in the enhancement of DNA single-strand scissions with no apparent effect on their rejoining.
    [Abstract] [Full Text] [Related] [New Search]