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  • Title: O-Allylated Pudovik and Passerini Adducts as Versatile Scaffolds for Product Diversification.
    Author: Kerim MD, Katsina T, Cattoen M, Fincias N, Arseniyadis S, El Kaïm L.
    Journal: J Org Chem; 2020 Oct 02; 85(19):12514-12525. PubMed ID: 32845144.
    Abstract:
    The palladium-catalyzed O-allylation of α-hydroxyphosphonates and α-hydroxyamides obtained from Pudovik and Passerini multicomponent reactions has allowed interesting and highly straightforward access to a variety of building blocks for product diversification. These post-functionalizations include a selective base- or ruthenium hydride-mediated isomerization/Claisen rearrangement cascade and a ring-closing metathesis that allows access to a variety of diversely functionalized phosphono-oxaheterocycles.
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