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  • Title: Familial aggregation of atopic dermatitis and co-aggregation of allergic diseases in affected families in Taiwan.
    Author: Huang YH, Huang LH, Kuo CF, Yu KH.
    Journal: J Dermatol Sci; 2020 Oct; 100(1):15-22. PubMed ID: 32873424.
    Abstract:
    BACKGROUND: Atopic dermatitis (AD) is contributed from a result of genetic and environmental interaction. The evidence for familial aggregation in AD has been reported but population-based studies and co-aggregation with other allergic diseases are rarely reported. OBJECTIVE: This study examined familial aggregation and heritability of atopic dermatitis (AD) and to estimate the relative risks (RRs) of other allergic diseases in individuals with relatives diagnosed with AD. METHODS: We used Taiwan National Health Insurance Research Database to identify all registered beneficiaries (n = 26,525,074) in 2015; among them, 1,248,594 individuals had AD. We estimated familial risks of AD and other allergic diseases by using marginal Cox proportional models. RESULTS: Prevalence of AD in individuals with relatives affected with atopic dermatitis was 3.1-fold higher than the general population (12.4 % vs. 4.0 %, respectively). The adjusted relative risks (RR) for individuals with an affected first-degree relative (FDR) was 2.25 (95 % CI, 2.25-2.26). The adjusted RRs for subjects with an affected parent, an affected offspring or an affected sibling was 2.39 (95 % CI, 2.37-2.41), 2.26 (95 % CI, 2.24-2.28) and 2.30 (95 % CI, 2.29-2.31) respectively. The RRs in individuals with an FDR with AD was 1.34 (95 %CI, 1.34 - 1.34) for asthma and 1.23 (95 %CI, 1.23-1.24) for allergic rhinitis. CONCLUSION: This nationwide study ascertains that a family history of atopic dermatitis is a risk factor for atopic dermatitis. Individuals with relatives affected by atopic dermatitis have slightly higher risks of developing asthma and allergic rhinitis.
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