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  • Title: Evaluation of a new strategy for detection of thyroid dysfunction in the routine laboratory.
    Author: John R, Henley R, Lloyd G, Elder GH.
    Journal: Clin Chem; 1988 Jun; 34(6):1110-4. PubMed ID: 3288375.
    Abstract:
    We assessed the use of a new strategy for detecting thyroid disorders, utilizing a sensitive assay for concentrations of thyrotropin (TSH) and free thyroid hormone in serum as follow-up tests. Of 1279 patients who were not on thyroxin (T4) replacement treatment, 82% could be classified as euthyroid and would require no further tests. In patients who were on T4 replacement, 41% fell into the euthyroid category and would require no further tests. Using this strategy to replace our existing strategy of free thyroxin as a "first-line" test would reduce the proportion of patients who would require one or more follow-up tests from 49% to 24%.
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