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  • Title: Detection of Streptococcus pneumoniae antigen in pleural fluid: usefulness of an immunofluorescence-based lateral flow assay for the diagnosis of pneumococcal pneumonia.
    Author: Romero Herrero D, Soler-Palacin P, Burgos Cibrian J, Falcó Ferrer V, Anton Pagarolas A, Martin-Gomez MT.
    Journal: Diagn Microbiol Infect Dis; 2020 Dec; 98(4):115162. PubMed ID: 32896751.
    Abstract:
    The performance of an immunofluorescence-based Streptococcus pneumoniae antigen detection test in pleural fluid (IF-PF) was evaluated. For proven and possible pneumococcal pneumonias global sensitivity and specificity were 92.6 (95 CI 76.6-97.9) and 80 (95 CI 62.7-90.5), respectively, with no significant differences between children and adults. Global diagnostic accuracy of IF-PF was 86% (74.2-93.7), and a substantial k index of concordance with culture/RT-PCR of 0.716 (0.535-0.896). IF-PF might be useful as a rapid complementary test for the etiologic diagnosis of pneumococcal pneumonia.
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