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  • Title: Function of a yeast TATA element-binding protein in a mammalian transcription system.
    Author: Buratowski S, Hahn S, Sharp PA, Guarente L.
    Journal: Nature; 1988 Jul 07; 334(6177):37-42. PubMed ID: 3290687.
    Abstract:
    Saccharomyces cerevisiae contains a protein which is functionally similar to the mammalian TATA element-binding transcription factor, TFIID. The yeast factor substitutes for TFIID in a mammalian RNA polymerase II in vitro transcription system, forms a stable preinitiation complex on the Adenovirus-2 major late promoter, and binds specifically to the TATA boxes of the viral promoter and the yeast CYC1 promoter. Interestingly, the yeast factor promotes initiation at a distance from the TATA element typical of a mammalian system.
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