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  • Title: [Reduction using an immunomodulator of the level of respiratory infections in chronic bronchitis].
    Author: Rochemaure J, Lehert P, Sauvaget J, Robillard M, Betbeder-Matibet A.
    Journal: Rev Pneumol Clin; 1988; 44(1):43-7. PubMed ID: 3291072.
    Abstract:
    Fifty-six patients with recurrent bronchopulmonary infections associated with chronic bronchitis were randomly allocated to 2 groups, to assess whether treatment with an immunomodulator, Diribiotin CK, could enhance resistance to infection. The double-blind, placebo-controlled prospective trial over a 9 month period showed that this immunomodulator was well tolerated and significantly reduced the rate of respiratory tract infection. The drug also significantly reduced the prescribing of antibiotic medication and the rate of absenteism from work. These effects have been demonstrated in a rigorously designed clinical study. This is the first time that a clear clinical activity has been attributed to an inducer of soluble mediators of immunity.
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