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Title: [Surgery technique of combined different infratemporal fossa approaches for lesions in lateral skull base].
Author: Wei XM, Gao ZQ, Xu ZQ, Yang H, Zhang ZH, Tian X, Zhao Y, Zhou YL, Feng GD.
Journal: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2020 Sep 07; 55(9):814-821. PubMed ID: 32911883.
Abstract:
Objective: To investigate the technical points and clinical application of combined infratemporal fossa approaches (CIFA) by analyzing the clinical results with CIFA for lesions involved skull base. Methods: A retrospective study was performed on 11 patients underwent CIFA for skull base lesions dissection from December 2014 to January 2019 in the department of otolaryngology, Peking Union Medical College Hospital. There were 6 male and 5 female patients, with age range of 16-72 years old and median age of 53 years old. Five patients underwent CIFA Type B and D, and the other 6 underwent CIFA A and B. All patients were followed up regularly by CT and MRI to observe possible recurrence. Results: Among the 5 patients with CIFA Type B and D, 3 were giant cell tumor and 2 were giant cell reparative granuloma, and median maximum cross-section size was 42 mm×46 mm (range from 37 mm×18 mm to 56 mm×53 mm). Among the 6 patients with CIFA Type A and B, 4 were paraganglioma of head and neck, 1 was schwannoma of skull base, 1 was petrous cholesteatoma, and median maximum cross-section size was 43 mm×36 mm (range from 24 mm×22 mm to 63 mm×35 mm). Nine patients underwent complete resection of the tumor in the first stage. In 2 patients, the extracranial parts were removed in the first stage, and the intracranial part was removed in the second stage. Tympanum and ossicular reconstruction were done in one of the CIFA Type B and group D, and 1 year's postoperative hearing was mild conductive hearing loss. There was no cerebrospinal fluid leakage of all patients. All the 5 patients with normal facial nerve function before surgery recovered to H-B grade Ⅰ to Ⅱ within 3 months after surgery. Among the 4 patients whose preoperative facial nerve function were grade Ⅱ, 2 recovered to grade I after surgery and the other 2 were still grade Ⅱ. For the patient whose preoperative facial nerve function was grade Ⅴ, his postoperative recovery was grade Ⅲ. There was 1 patient whose pre-operative FN function was H-B grade Ⅲ, and the post-operative FN function was grade Ⅵ due to FN resection. Except for 2 cases with cochlear involved before surgery, cochleae of the other 9 cases were preserved. The follow-up time was 14 to 58 months. No recurrence was observed in all patients. Conclusions: The CIFA can safely and completely remove the extensive lesions that invade the skull base, and the facial nerve function can be well protected and recovered intro-and post-operation. Appropriate use of combined IFA can not only achieve good exposure and complete resection of lesions, but also create conditions for functional reconstruction. 目的： 通过总结颞下窝联合进路（combined infratemporal approach，CIFA）切除颅底病变的临床效果，探讨其技术要点和临床应用价值。 方法： 回顾性分析2014年12月至2018年7月在北京协和医院耳鼻咽喉科因颅底肿物行CIFA切除病变的11例患者的临床资料。其中男性6例，女性5例；年龄16~71岁，中位年龄53岁。其中5例患者采用CIFA Type B+D切除病变，6例采用CIFA Type A+B切除病变。术后定期复查颞骨增强MRI判断有无肿瘤复发。 结果： 5例采用CIFA Type B+D术式的患者中3例为颞骨巨细胞修复性肉芽肿，2例为颞骨骨巨细胞瘤，肿瘤最大横截面的中位数为42 mm×46 mm(范围37 mm×18 mm~56 mm×53 mm）；6例采用CIFA Type A+B术式的患者中4例为头颈部副神经节瘤，1例为颅底神经鞘瘤，1例为岩尖胆脂瘤，肿瘤最大横截面的中位数为43 mm×36 mm（范围24 mm×22 mm~63 mm×35 mm）。11例患者中9例一期手术完整切除肿瘤，2种术式中各有1例分二期切除病变（一期切除颅外部分，二期切除侵入颅内的部分）。CIFA Type B+D组中有1例重建了鼓室和听力，术后1年听力为轻度传导性听力下降。所有患者术后均未发生脑脊液漏。术前面神经功能正常的5例患者，术后面神经功能均在3个月内恢复到House-Brackmann分级（H-B）Ⅰ~Ⅱ级；术前面神经功能为Ⅱ级的4例患者，术后有2例恢复为Ⅰ级，另外2例仍为Ⅱ级；1例术前面神经功能为Ⅲ级的患者由于术中切除面神经术后面神经功能为Ⅵ级，1例术前面神经功能为Ⅴ级的患者，术后恢复为Ⅲ级。2例术前已有耳蜗破坏，术中予以切除，其余9例均保留了耳蜗。术后随访14~58个月，均未见病变复发。 结论： CIFA技术可以安全、彻底切除广泛侵犯侧颅底的占位病变，术中及术后耳蜗、面神经功能得到较好的保护与恢复。灵活运用CIFA技术，不仅可以实现病变的良好暴露和完整切除，还可为功能重建创造条件。.

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