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  • Title: [Changes in transmitter release at frog neuromuscular junction induced by 4-aminopyridine].
    Author: Molgo J, Lemeignan M, Lechat P.
    Journal: C R Acad Hebd Seances Acad Sci D; 1975 Nov 24; 281(21):1637-9. PubMed ID: 3292.
    Abstract:
    4-aminopyridine (4-AP) at micromolar concentrations, increases the end-plate potential amplitude in curarized preparations and the mean quantal content in every preparation tested, but the spontaneous release is not modified by 4-AP. These results can explain the anticurare activity observed in the wole animal or in vitro. 4-AP prolongs the falling phase of the muscle action potential without change in the muscle membrane potential.
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