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  • Title: [Clonogenic cultivation of bone marrow fibroblast precursors in human myeloproliferative diseases].
    Author: Kolosova LIu, Vladimirskaia EB, Kovaleva LG.
    Journal: Eksp Onkol; 1988; 10(2):46-8. PubMed ID: 3292215.
    Abstract:
    Techniques of clonogenic cultivation with the application of xenogenous feeder (rabbit irradiated bone marrow) were used to study a number of bone marrow colony-forming cells (CFU-F) in 70 patients. A significant increase of CFU-F is observed in chronic myelocytic leukemia and in hepatosplenomegalies of non-leukemic origin CFU-F decreases considerably in the cases of myelofibrosis. Trypsinisation of the bone marrow taken from the cases of myelofibrosis results in a sharp CFU-F increase.
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