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  • Title: A new xanthone dimer and cytotoxicity from the stem bark of Calophyllum canum.
    Author: Taher M, Salleh WMNHW, Alkhamaiseh SI, Ahmad F, Rezali MF, Susanti D, Hasan CM.
    Journal: Z Naturforsch C J Biosci; 2021 Jan 27; 76(1-2):87-91. PubMed ID: 32931451.
    Abstract:
    A phytochemical investigation of the stem bark of Calophyllum canum resulted in the isolation of a new xanthone dimer identified as biscaloxanthone (1), together with four compounds; trapezifoliaxanthone (2), trapezifolixanthone A (3), taraxerone (4) and taraxerol (5). The structures of these compounds were determined via spectroscopic methods of IR, UV, MS and NMR (1D and 2D). The cytotoxicity of compounds 1-3 were screened against A549, MCF-7, C33A and 3T3L1 cell lines, wherein weak cytotoxic activities were observed (IC50 > 50 μm).
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