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  • Title: Copper-catalyzed aerobic oxidative C-C bond cleavage of simple ketones for the synthesis of amides.
    Author: Yang GP, Li K, Liu W, Zeng K, Liu YF.
    Journal: Org Biomol Chem; 2020 Sep 21; 18(35):6958-6964. PubMed ID: 32936187.
    Abstract:
    A Cu-catalyzed oxidative amidation of simple ketones with amines via carbon-carbon (C-C) bond cleavage has been developed. A number of aryl and alkyl ketones could be easily converted to amides using cheap copper salt as the catalyst and O2 as the oxidant with a wide range of amines, including primary and secondary amines. This method shows a notable advantage of the broad scope for the substrate, thus providing a practical approach to amides. A plausible mechanism is proposed based on the preliminary experiments.
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