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  • Title: White matter lesions in multiple sclerosis are enriched for CD20dim CD8+ tissue-resident memory T cells.
    Author: Hsiao CC, Fransen NL, van den Bosch AMR, Brandwijk KIM, Huitinga I, Hamann J, Smolders J.
    Journal: Eur J Immunol; 2021 Feb; 51(2):483-486. PubMed ID: 32949467.
    Abstract:
    Brain CD8+ CD69+ tissue-resident memory T (TRM ) cells comprise a CD20dim subset, which is proportionally larger in CD103-negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM -cell proportions are increased. CD20-expression is associated with higher levels of CXCR6, Ki-67, and granzyme B, supporting CD20dim TRM cells as a relevant subset in MS.
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