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  • Title: Vasopressin coexists in half of the corticotropin-releasing factor axons present in the external zone of the median eminence in normal rats.
    Author: Whitnall MH, Smyth D, Gainer H.
    Journal: Neuroendocrinology; 1987 May; 45(5):420-4. PubMed ID: 3295576.
    Abstract:
    Electron-microscopic immunocytochemistry of serial thin sections showed that, in normal rats, approximately 50% of corticotropin-releasing factor (CRF) axons in the external zone of the median eminence contained vasopressin (AVP) and AVP precursor-derived peptides coexistent in the same secretory vesicles as CRF. The other 50% of the CRF axons contained little or no detectable AVP or AVP precursor-derived peptides. Differential activation of these subpopulations of CRF axons could provide a mechanism by which levels of CRF and AVP in portal plasma could be varied independently.
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