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  • Title: Systemic administration of MK-801 prevents N-methyl-D-aspartate-induced neuronal degeneration in rat brain.
    Author: Foster AC, Gill R, Kemp JA, Woodruff GN.
    Journal: Neurosci Lett; 1987 May 19; 76(3):307-11. PubMed ID: 3295603.
    Abstract:
    MK-801 is a novel, potent and selective non-competitive antagonist of the N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptors. Pretreatment of rats with MK-801 (1-10 mg/kg, i.p.) prevented neuronal degeneration in the hippocampus and striatum caused by direct intracranial injections of NMDA (20-120 nmol), but did not protect against the loss of neurones induced by kainate (2.5 nmol) injected into the striatum. Thus, MK-801 is a selective antagonist of neuronal degeneration caused by excessive stimulation of NMDA receptors in vivo.
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