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  • Title: [Nuclear receptors in estrogen receptor negative tumors with progesterone receptors].
    Author: Geyer H, Braun A.
    Journal: Onkologie; 1987 Apr; 10(2):79-82. PubMed ID: 3295630.
    Abstract:
    The nuclear estrogen receptors ERn were determined in 12 carcinomas whose cytoplasm contained progesterone receptors PRc but no estrogen receptors ERc. ERn were found in 9 of the tumors. Their concentration correlated to those of PRc and reached a mean of only 20% of the ERn concentrations found in ERc+/PRc + carcinomas. These results suggest that in carcinomas of the ERc-/PRc+-type, originally present cytoplasmic estrogen receptors induce the synthesis of progesterone receptors in a concentration corresponding to that of the nuclear receptors, following translocation by endogenous estradiol in the nucleus.
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